Ruaridh McConnochie has again been named to begin for England following two false starts, while Owen Farrell captains the group at fly-half.
Last month, the uncapped McConnochie was first scheduled to start in a set of World Cup warm-up fixtures, but pulled out of the two games because of injury.
The Toilet winger will make his debut England face Italy in their in Newcastle, live on Sky Sports.
Farrell wears the No 10 jersey while Piers Francis begins at inside centre George Ford chooses his place on the seat.
More to follow…
England: 15 Anthony Watson, 14 Ruaridh McConnochie, 13 Joe Marchant, 12 Piers Francis, 11 Jonny May, 10 Owen Farrell (c), 9 Ben Youngs, 1 Joe Marler, 2 Jamie George, 3 Dan Cole, 4 Joe Launchbury, 5 Courtney Lawes, 6 Tom Curry, 7 Mark Wilson, 8 Billy Vunipola.
Replacements: 16 Luke 17 Ellis Genge, 18 Kyle Sinckler, 19 Charlie Ewels, 20 Matt Kvesic, 21 Willi Heinz, 22 George Ford, 23 Joe Cokanasiga.